In Vitro Vascular Activity
Isolated vessel ring assays for preclinical vasoactivity profiling
Vessel ring studies are a powerful, controlled method to assess vasoconstriction and vasorelaxation properties of test compounds. At CorDynamics, in vitro vascular activity assays support early cardiovascular liability screening, lead optimization, and safety pharmacology using reliable contractile tissues from various sources.
Preclinical In Vitro Vascular Activity Studies
These assays use isolated arterial or venous rings—mounted in tissue bath systems—to measure real-time contractile responses under tightly regulated experimental conditions. Because the environment excludes neural, hormonal, and flow-based confounders, the technique offers a clean readout of direct vascular effects.
Study designs can include:
- Concentration-response assessments of contractile and relaxation effects
- Endothelium-intact vs. denuded vessel comparisons to investigate mechanism of action
- Tissue source flexibility, including thoracic aorta, mesenteric artery, coronary artery, pulmonary artery, and human mammary artery rings
- Perfusate customization and temperature-controlled chambers to simulate physiological conditions
Vascular ring studies are widely used to:
- Identify and rank vasoconstrictive or vasodilatory liabilities
- Support mechanism-of-action studies and backup compound comparisons
- Complement in vivo hemodynamic or telemetry data
- Establish PK/PD relationships in early screening programs
Why Choose CorDynamics
CorDynamics offers decades of vascular physiology expertise, with validated protocols across species and vessel types. Our team routinely integrates vascular activity studies into both exploratory and regulated preclinical programs.
Each assay is designed for precision, reproducibility, and interpretation in the context of broader cardiovascular goals. LabChart software ensures high-fidelity signal acquisition and real-time analysis of tension, tone, and responsiveness.
High-resolution vessel ring studies to assess vascular effects early and with confidence.
