CorDynamics has extensive experience working with project teams throughout their drug discovery steps—including a number of models for investigating atrial fibrillation.
Isolated Langendorff Heart
Poised for early discovery screening studies, including electrophysiology data
Compound sparing
Rapid turnaround with flexible design
Anesthetized canine
Acute induction via vagal pacing with epinephrine
Complete cardiac electrophysiology available (atrial, AV nodal, His bundle, ventricular)
Telemetry
Complex atrial tachypaced models available
DRUG DISCOVERY
Chronic rapid atrial pacing in canines—electrical and structural remodeling consistent with the clinical scenario
Inducible AF with complete electrophysiology measurements
Concurrent ECG and hemodynamics
Multiple compounds in the same animal (consistent with 3Rs)
Provide a detailed interrogation alongside tolerability and PK/PD information
